Figure 6.

Oxytocin-Sensitive Neurons Modulate the Switch between Active and Passive Responses to Imminent Threat

(A) HE rats received injections with vehicle (gray) or OTA (green) that were targeted through cannulae intracerebrally (i.c.) into the CeL. 15 min later, both groups were tested for responses to distant threats (4 kHz, yellow) and imminent threats (12 kHz, orange) in the TET.

(B) OTA in HE rats reduced escape to imminent, but not distant, threat (two-way ANOVA: treatment × imminence F_{(1, 22)} = 16.57; p < 0.001). ^∗p < 0.05.

(C) OTA in HE rats increased freezing both to distant and imminent threat (two-way ANOVA: imminence effect F_{(1, 18)} = 13.73, p < 0.01; treatment effect F_{(1, 18) =} 36.30, p < 0.001; n = 6–7 each group). ^∗∗p < 0.01.

(D) LE rats received injections with vehicle (black) or TGOT (blue) that were targeted through cannulae intracerebrally (i.c.) into the CeL. 15 min later, both groups were tested for responses to distant threats (4kHz, yellow) and imminent threats (12 kHz, orange) in the TET.

(E) TGOT increased escape to imminent, but not distant, threat (two-way ANOVA: imminence effect F_{(1, 22)} = 55.36, p < 0.001; treatment effect F_{(1, 22)} = 2.95, p < 0.01). ^∗∗p < 0.01.

(F) TGOT decreased freezing to imminent, but not distant, threat (two-way ANOVA: imminence × treatment effect F_{(1, 20)} = 7.27, p < 0.05; n = 6–7 each group). ^∗∗p < 0.01.

(G) Localization of microinjector tips for each animal according to brain atlas of Paxinos and Watson (1997).

Error bars represent standard error of the mean. See also Figure S5.