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Disparity in CDR definitions according to Kabat (hypervariable regions) (A, C) and Chothia (structural loops) (B, D) shown on the 1kiq domain structures. The variable domain 3D structures of the light (A, B) and heavy (C, D) chain are represented in cartoon with the frameworks in gray and CDR highlighted in red according to Kabat (A, C) and Chothia (B, D) numbering scheme.
