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. 2018 Oct 16;9:2278. doi: 10.3389/fimmu.2018.02278

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Copyright © 2018 Dondelinger, Filée, Sauvage, Quinting, Muyldermans, Galleni and Vandevenne.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representation of the “two-span-bridge” conformation of CDRL1 present in the 2fb4 antibody structure. The two-span-bridge is represented in gray and the bordering strands are shown in yellow (A, B). (A) Shows the isolated loop with an Ile side chain (colored red) pointing inwards the loop structure. (B) The complete domain showing how the Ile penetrates deeply into the core of the light chain variable domain making hydrophobic interactions with neighboring residues organized in a pocket (purple spheres).