Table 1.
Introduction of anthelmintic drugs and development of resistance.
| Anthelmintic class | Generic name | Market release | Reported resistance |
|---|---|---|---|
| Heterocyclic compounds | Phenothiazine | 1940 | 1957 |
| Piperazine | 1954 | 1966 | |
| Benzimidazoles | Thiabendazole | 1961 | 1964 |
| Cambendazole | 1970 | 1975 | |
| Oxibendazole | 1970 | 1985 | |
| Mebendazole | 1972 | 1975 | |
| Albendazole | 1972 | 1983 | |
| Fenbendazole | 1975 | 1982 | |
| Oxfendazole | 1976 | 1981 | |
| Triclabendazole | 1983 | 1998 | |
| Imidazothiazoles and | Levamisole | 1970 | 1979 |
| Tetrahydropyrimides | Pyrantel | 1974 | 1996 |
| Oxantel | 1976 | / | |
| Morantel | 1970 | 1979 | |
| Macrocyclic lactones | Abamectin | Late '70 | 2001 |
| Ivermectin | 1981 | 1988 | |
| Moxidectin | 1991 | 1995 | |
| Doramectin | 1993 | 2007 | |
| Eprinomectin | 1996 | 2003 | |
| Amino-acetonitrile derivate | Monepantel | 2009 | 2013 |
Table adapted from De Graef et al. (15).