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. 2018 Nov;22(11):1011–1025. doi: 10.1016/j.tics.2018.08.006

Figure 1.

Figure 1

Connectivity of the MD in Primates. (A) On the left side: connections between the magnocellular MD and the ventromedial and orbitofrontal areas of the PFC. On the right side: connections between the parvocellular MD and the lateral PFC. (B) Overlap of the medial lesions involving the MD of 12 stroke patients (modified from [36]). (C) fMRI activation maps involving the MD and the PFC during episodic retrieval in healthy subjects (modified from [73]). (D) Diagram showing the structural connectivity of the magnocellular MD and the parvocellular MD. Blue arrows correspond to excitatory connections. Orange arrows correspond to inhibitory connections. Abbreviations: ACC, anterior cingulate cortex; CeM, central medial thalamic nucleus; CL, central lateral thalamic nucleus; CM, centromedian thalamic nucleus; DLPFC, dorsolateral prefrontal cortex; DMPFC, dorsomedial prefrontal cortex; GPe, external globus pallidus; Hb, habenula; Ic, internal capsule; MD, mediodorsal thalamic nucleus; MDmc, magnocellular subdivision of the mediodorsal thalamic nucleus; MDpc, parvocellular subdivision of the mediodorsal thalamic nucleus; mtt, mammillothalamic tract; OFC, orbitofrontal cortex; PFC, prefrontal cortex; PuT, putamen; R, thalamic reticular nucleus; SNr, substantia nigra pars reticulata; TRN, thalamic reticular nucleus; VA, ventral–anterior thalamic nucleus; VLPFC, ventrolateral prefrontal cortex; VMPFC, ventromedial prefrontal cortex; VTA, ventral tegmental area.