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. 2018 Oct 9;20:1062–1069. doi: 10.1016/j.nicl.2018.10.005

Fig. 3.

Fig. 3

(A) Whole brain-based spatial statistics (WBSS) of FA maps at the group level for ALS patients, PLS patients, and controls. WBSS of FA maps demonstrated multiple clusters of regional FA reductions at p < 0.05 (corrected for multiple comparisons), projectional views. (B) Tractwise fractional anisotropy statistics (TFAS) of FA maps at the group level for ALS patients, PLS patients, and controls. TFAS demonstrated significant regional FA reductions in ALS-related tract systems and in the grand average between ALS patients and controls as well as between PLS patients and controls. No alterations between groups were observed in the reference tract. * p < 0.05, ** p < 0.001.