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(A) Mean arterial blood pressure (MABP), (B) renal vascular resistance (RVR), (C) the absolute effect of benzamil on fractional excretion of Na+ (Δ FEN a(benz)), and (D) K+ (Δ FEK (benz)) in P2X4+/+ (■) and P2X4−/− (□) mice on either a standard (n = 8 and 7, respectively) or a low Na+ diet for 14 days (n = 7 and 6, respectively). Data are mean ± SEM, and comparisons were made with ANOVA using Bonferroni post‐hoc testing. *P < 0.05; **P < 0.01; ***P < 0.001.
