Table 2.

Annual percent change in brain glioma incidence rates by histology subtypes: SEER 9, 1973‐2014

	Trend 1			Trend 2			Trend 3			Trend 4			2005‐2014
	Year	APC	95% CI	Year	APC	95% CI	Year	APC	95% CI	Year	APC	95% CI	AAPC	95% CI
Glioma (overall)	1973‐1985	2.4	1.7, 3.1a	1985‐2014	−0.5	−0.6, −0.3a							−0.5	−0.6, −0.3a
Nonglioblastoma	1973‐1977	33.1	21.0, 46.4a	1977‐1982	3.6	−2.5, 9.9	1982‐2014	−2.2	−2.5, −2.0a				−2.2	−2.5, −2.0a
Astrocytoma	1973‐1977	38.6	27.9, 50.2a	1977‐1987	0.7	−0.7, 2.1	1987‐2001	−6.8	−7.6, −5.9a	2001‐2014	−0.1	−1.2, 0.9	−0.1	−1.2, 0.9
Oligodendroglioma	1973‐1989	3.9	2.1, 5.7a	1989‐1998	11.3	8.3, 14.4a	1998‐2014	−4.4	−5.2, −3.6a				−4.4	−5.2, −3.6a
Mixed oligoastrocytoma	1973‐1980	29.8	3.7, 62.4a	1980‐2011	2.6	1.7, 3.4a	2011‐2014	−15.9	−34.5, 7.9				−4.0	−11.4, 4.0
Glioblastoma	1973‐1978	−7.3	−11.0, −3.3a	1978‐1992	2.7	1.8, 3.6a	1992‐2014	0.3	0.0, 0.6a				0.3	0.0, 0.6a

AAPC, average annual percent change; APC, annual percent change; CI: confidence interval.

^aThe value is statistically different from zero (2‐sided P < 0.05) based on joinpoint regression analysis.