Table 3.
Most likely clusters of childhood cancer detected by SaTScan and FleXScan, on the living zone and département scales (2000‐2014)
| Diagnostic groups and subgroups | N | 1898 LZ | 94 Départements | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SaTScan | FleXScan | SaTScan | FleXScan | ||||||||||||||
| Units | O | E | P | Units | O | E | P | Units | O | E | P | Units | O | E | P | ||
| Malignant hematopoietic tumors | |||||||||||||||||
| Leukemias, myeloproliferative and myelodysplastic diseases | 7447 | 94 | 325 | 262.1 | 0.93 | 11 | 55 | 28.2 | 0.49 | 11 | 562 | 490.6 | 0.55 | 12 | 893 | 774.9 | 0.12 |
| Acute lymphoid leukemias | 5854 | 51 | 166 | 118.7 | 0.69 | 13 | 67 | 32.5 | 0.10 | 17 | 698 | 611.0 | 0.25 | 12 | 731 | 621.2 | 0.06 |
| Acute myeloid leukemias | 1078 | 7 | 8 | 1.2 | 0.64 | 6 | 11 | 2.4 | 0.71 | 7 | 233 | 191.9 | 0.59 | 11 | 208 | 161.8 | 0.40 |
| Lymphomas | 2832 | 48 | 132 | 85.3 | 0.09 | 6 | 17 | 4.5 | 0.45 | 17 | 431 | 358.7 | 0.09 | 9 | 285 | 216.1 | 0.04 |
| Hodgkin lymphomas | 1262 | 94 | 84 | 51.2 | 0.43 | 7 | 13 | 3.1 | 0.63 | 5 | 69 | 41.5 | 0.10 | 6 | 79 | 48.7 | 0.21 |
| Burkitt l ymphomas | 699 | 4 | 9 | 1.0 | 0.07 | 5 | 10 | 1.2 | 0.07 | 19 | 129 | 96.8 | 0.42 | 12 | 131 | 92.0 | 0.18 |
| Other lymphomas | 871 | 5 | 12 | 1.3 | <0.01 | 5 | 12 | 1.3 | 0.01 | 3 | 37 | 18.6 | 0.15 | 11 | 85 | 50.0 | 0.04 |
| CNS tumors | 6359 | 97 | 325 | 240.7 | 0.02 | 23 | 213 | 138.7 | 0.02 | 11 | 497 | 392.9 | <0.01 | 9 | 478 | 367.3 | <0.01 |
| Ependymomas and choroid plexus tumors | 625 | 5 | 10 | 1.3 | 0.08 | 2 | 5 | 0.4 | 0.42 | 6 | 43 | 28.2 | 0.94 | 13 | 73 | 50.3 | 0.86 |
| Embryonal CNS tumors | 1228 | 12 | 12 | 2.7 | 0.53 | 3 | 7 | 1.1 | 0.90 | 17 | 156 | 118.6 | 0.35 | 12 | 122 | 86.3 | 0.43 |
| Gliomas | 3898 | 57 | 204 | 131.9 | <0.01 | 22 | 136 | 77.0 | 0.01 | 11 | 337 | 241.3 | <0.01 | 10 | 328 | 225.2 | <0.01 |
| Pilocytic astrocytomas | 1409 | 8 | 11 | 2.7 | 0.91 | 9 | 28 | 12.2 | 0.85 | 9 | 243 | 200.7 | 0.64 | 12 | 202 | 171.5 | 0.66 |
| Other gliomas | 2489 | 97 | 159 | 95.1 | <0.01 | 33 | 75 | 28.5 | <0.01 | 11 | 230 | 154.4 | <0.01 | 8 | 204 | 129.4 | <0.01 |
| Embryonal tumors | |||||||||||||||||
| Neuroblastomas | 2101 | 65 | 127 | 83.5 | 0.22 | 13 | 38 | 16.1 | 0.31 | 6 | 184 | 137.1 | 0.10 | 13 | 380 | 309.2 | 0.12 |
| Retinoblastomas | 742 | 45 | 33 | 16.8 | 0.99 | 8 | 17 | 5.3 | 0.53 | 2 | 49 | 28.7 | 0.31 | 7 | 143 | 99.4 | 0.08 |
| Nephroblastomas | 1415 | 18 | 14 | 3.0 | 0.18 | 14 | 24 | 5.6 | 0.03 | 11 | 270 | 221.9 | 0.39 | 12 | 301 | 240.8 | 0.20 |
| Hepatoblastomas | 218 | 2 | 3 | 0.1 | 0.63 | 1 | 2 | 0.0 | 0.60 | 2 | 7 | 1.6 | 0.56 | 11 | 36 | 21.1 | 0.84 |
| Malignant bone and soft tissue tumors | |||||||||||||||||
| Malignant bone tumors | 1225 | 41 | 31 | 13.4 | 0.60 | 10 | 23 | 8.6 | 0.68 | 6 | 62 | 37.2 | 0.16 | 8 | 106 | 70.1 | 0.18 |
| Osteosarcomas | 576 | 4 | 6 | 0.5 | 0.37 | 4 | 6 | 0.5 | 0.31 | 6 | 125 | 91.7 | 0.23 | 14 | 181 | 138.9 | 0.26 |
| Ewing tumors | 556 | 32 | 14 | 3.2 | 0.25 | 4 | 6 | 0.5 | 0.23 | 3 | 16 | 5.5 | 0.22 | 7 | 34 | 16.8 | 0.40 |
| Soft tissue and other extraosseous sarcomas | 1654 | 4 | 6 | 0.6 | 0.60 | 8 | 14 | 4.3 | 0.95 | 7 | 187 | 150.6 | 0.74 | 12 | 395 | 330.4 | 0.30 |
| Rhabdomyosarcomas | 899 | 2 | 6 | 0.7 | 0.87 | 2 | 6 | 0.7 | 0.80 | 9 | 98 | 72.7 | 0.77 | 12 | 249 | 203.0 | 0.51 |
| Other soft tissue sarcomas | 755 | 60 | 28 | 11.9 | 0.69 | 6 | 9 | 2.0 | 0.87 | 12 | 122 | 90.4 | 0.40 | 10 | 113 | 81.0 | 0.55 |
| Germ‐cell tumors, trophoblastic tumors, and neoplasms of gonads | 836 | 33 | 24 | 8.4 | 0.25 | 2 | 7 | 1.4 | 0.99 | 5 | 106 | 78.8 | 0.68 | 10 | 166 | 127.6 | 0.54 |
| Intracranial and intraspinal GCTs | 229 | 7 | 4 | 0.33 | 0.95 | 2 | 2 | 0.1 | 0.98 | 4 | 12 | 4.72 | 0.83 | 10 | 23 | 10.76 | 0.73 |
| Malignant extracranial and extragonadal GCT | 263 | 5 | 5 | 0.35 | 0.42 | 1 | 3 | 0.1 | 0.33 | 5 | 11 | 3.69 | 0.62 | 13 | 33 | 16.15 | 0.35 |
| Malignant gonadal GCT | 318 | 44 | 17 | 4.8 | 0.28 | 2 | 4 | 0.3 | 0.72 | 7 | 73 | 53.8 | 0.89 | 9 | 84 | 60.2 | 0.81 |
| All cancers | 25 877 | 82 | 1210 | 1061.4 | 0.26 | 26 | 720 | 587.8 | 0.12 | 10 | 1789 | 1605.2 | 0.01 | 10 | 2519 | 2278.7 | 0.01 |
CNS, Central nervous system; GCT, Germ cell tumors.
N: total number of observed cases (islands excluded). units: number of geographic units (LZ or département) included in the most likely cluster zone. O and E: observed and expected numbers of cases in the most likely cluster zone. P: statistical significance threshold after 999 and 9999 Monte Carlo simulations on the LZ and département scales, respectively.