Table 4.

Time variation in the incidence rate of childhood cancer in France over 2000‐2014

Diagnostic groups and subgroups	Na	Φb	AAPC (%)	95% CIc	P‐value
Malignant hematopoietic tumors
Leukemias, myeloproliferative, and myelodysplastic diseases	7447		0.1	−0.4; 0.7	0.64
Acute lymphoid leukemias	5854		0.4	−0.2; 1.0	0.23
Acute myeloid leukemias	1078		−0.6	−2.0; 0.8	0.38
Lymphomas	2832		−1.1	−1.9; −0.2	0.01
Hodgkin lymphomas	1262		−0.3	−1.6; 0.9	0.60
Burkitt lymphomas	699		−2.2	−3.8; −0.5	0.01
Other lymphomas	871		−1.2	−2.7; 0.3	0.12
CNS tumors	6359		0.4	−0.1; 1.0	0.13
Ependymomas and choroid plexus tumors	625		0.8	−1.0; 2.6	0.39
Embryonal CNS tumors	1228		−0.9	−2.2; 0.4	0.17
Gliomasd	3898	1.8	0.9	0.0; 1.9	0.05
Pilocytic astrocytomasd	1409	1.8	−0.6	−2.0; 0.9	0.46
Other gliomasd	2489		1.8	0.9; 2.7	<0.01
Embryonal tumors
Neuroblastomas	2101		−0.4	−1.4; 0.6	0.40
Retinoblastomas	742		−0.7	−2.4; 0.9	0.40
Nephroblastomas	1415		−0.1	−1.3; 1.2	0.93
Hepatoblastomas	218		1.9	−1.2; 5.1	0.23
Malignant bone and soft tissue tumors
Malignant bone tumors	1225		−0.4	−1.7; 0.9	0.53
Osteosarcomasd	576	1.6	−0.9	−3.1; 1.3	0.43
Ewing tumors	556		0.7	−1.2; 2.7	0.47
Soft tissue and other extraosseous sarcomas	1654		−0.1	−1.2; 1.0	0.80
Rhabdomyosarcomas	899		0.1	−1.4; 1.6	0.88
Other soft tissue sarcomas	755		−0.5	−2.1; 1.2	0.59
Germ‐cell tumors, trophoblastic tumors, and neoplasms of gonads	836		−1.9	−3.4; −0.3	0.02
Intracranial and intraspinal GCT	229		−1.2	−4.1; 1.8	0.42
Malignant extracranial and extragonadal GCTe	263	1.7	−1.9	−5.1; 1.4	0.25
Malignant gonadal germ cell tumors	318		−2.6	−5.0; −0.1	0.04
Boyse	110		−5.4	−9.4; −1.1	0.01
Girlse	208		−1.1	−4.1; 2.1	0.51
All cancers	25 877		−0.1	−0.3; 0.2	0.69

AAPC: average annual percent change; CNS, Central Nervous System; GCT, Germ Cell Tumors.

Results have to be interpreted with caution.

^aNumber of cases.

^bΦ: degree of overdispersion estimated by the ratio of the deviance of the Poisson regression model to the number of degrees of freedom.

^cAverage annual Percent Change and the 95% confidence interval estimated with a Poisson regression model.

^dBinomial negative model.

^eLess than 15 cases per year on average.