Table V.

Proteins detected in culture media from embryos developing into blastocysts or that arrested. The median is based on normalized protein expression.

	Arrested embryos n = 17			Blastocysts n = 30		P value	Background CCM™ medium
	n	median (range)	n		median (range)		conditioned medium	fresh medium
VEGF-A	17	2.3 (2.0–3.2)	28		2.4 (1.8–4.6)	0.472	2.1 (2.1–2.1)	2.1 (2.0–2.2)
IL-6	15	2.1 (1.1–4.9)	28		3.2 (0.9–5.3)a	0.059	n.d.	n.d.
EMMPRIN	17	2.9 (2.7–4.2)	28		3.3 (2.6–4.2)**	0.003	2.3 (2.3–2.3)	2.4 (2.4– 2.4)
PlGF	17	0.8 (0.5–2.7)	27		0.8 (0.5–4.6)	0.274	0.6 (0.6–0.7)	0.6 (0.5–0.6)
Cystatin B	17	1.4 (0.8–2.2)	27		1.3 (0.8–3.5)	0.752	1.0 (1.0–1.1)	0.9 (0.8–1.0)
EpCAM	17	3.5 (2.6–5.5)	28		3.6 (2.7–7.2)	0.489	2.9 (2.9–2.9)	2.8 (2.8–2.9)
Caspase-3	15	1.8 (0.8–2.5)	28		1.4 (0.4–5.3)a	0.076	n.d.	n.d.
HE-4	16	0.7 (0.4–1.2)	28		0.7 (0.4–1.0)	0.980	n.d.	n.d.
IL-8	16	0.9 (0.6–3.7)	24		(0.5–6.1)	0.978	0.8 (0.8 – 0.8)	n.d.

^**P < 0.01 compared with arrested embryos, Mann–Whitney U test.

^aTendency.

n.d. = not detected.