Table VI.

Proteins detected in culture media from embryos developing into low- or high-quality blastocysts (n = 30). The median is based on normalized protein expression.

	Low-quality blastocysts n = 7		High-quality blastocysts n = 23		P value	Background CCM™ medium
	n	median (range)	n	median (range)		conditioned medium	fresh medium
VEGF-A	6	1.9 (1.8–3.5)	22	2.4 (2.1–4.6)a	0.052	2.1 (2.1–2.1)	2.1 (2.0–2.2)
IL-6	6	2.5 (0.9–4.7)	22	3.2 (1.1–5.3)	0.369	n.d.	n.d.
EMMPRIN	6	3.3 (3.1–3.8)	22	3.3 (2.6–4.2)	0.822	2.3 (2.3–2.3)	2.4 (2.4–2.4)
PlGF	5	0.7 (0.5–2.3)	22	0.8 (0.6–4.6)	0.413	0.6 (0.6–0.7)	0.6 (0.5–0.6)
Cystatin B	6	1.2 (0.8–2.0)	21	1.3 (1.0–3.5)	0.597	1.0 (1.0–1.1)	0.9 (0.8–1.0)
EpCAM	6	3.4 (2.7–4.6)	22	3.7 (2.7–7.2)	0.261	2.9 (2.9–2.9)	2.8 (2.8–2.9)
Caspase-3	6	1.8 (1.3–2.6)	22	1.2 (0.4–5.3)*	0.043	n.d.	n.d.
HE-4	6	0.6 (0.4–0.9)	22	0.7 (0.4–1.0)	0.495	n.d.	n.d.
IL-8	3	(1.0–1.7)	21	(0.5–6.1)	0.123	0.8 (0.8–0.8)	n.d.

^*P < 0.05 compared with low-quality blastocysts, Mann–Whitney U test.

^aTendency.

n.d.: not detected.