Table 2.
Univariate and multivariate analyses of OS and CSS for different variables of NSCLC before PSM
| Characteristicb | Univariate | Multivariate | ||||||
|---|---|---|---|---|---|---|---|---|
| OS | CSS | OS | CSS | |||||
| HR (95% CI)a | P a | HR (95%CI)a | P a | HR (95%CI)a | P a | HR (95%CI)a | P a | |
| Age (<66 as ref.) | 1.3 (1.3‐1.31) | <0.001 | 1.3 (1.2‐1.3) | <0.001 | 1.2 (1.1‐1.2) | <0.001 | 1.1 (1.1‐1.2) | <0.001 |
| Gender (Female as ref.) | 1.2 (1.2‐1.3) | <0.001 | 1.2 (1.2‐1.2) | <0.001 | 1.2 (1.2‐1.2) | <0.001 | 1.2 (1.2‐1.2) | <0.001 |
| Race (White as ref.) | ||||||||
| Black | 1.0 (1.0‐1.0) | 0.874 | 1.0 (0.9‐1.0) | 0.876 | 1.0 (0.9‐1.0) | 0.019 | 1.0 (0.9‐1.0) | <0.001 |
| Other | 0.72 (0.70‐0.75) | <0.001 | 0.72 (0.69‐0.75) | <0.001 | 0.73 (0.70‐0.76) | <0.001 | 0.72 (0.69‐0.75) | <0.001 |
| Marital (Married as ref.) | 1.2 (1.2‐1.2) | <0.001 | 1.2 (1.1‐1.2) | <0.001 | 1.1 (1.1‐1.1) | <0.001 | 1.1 (1.1‐1.1) | <0.001 |
| Histology (AD as ref.) | ||||||||
| SQC | 1.3 (1.2‐1.3) | <0.001 | 1.3 (1.2‐1.3) | <0.001 | 1.1 (1.1‐1.2) | <0.001 | 1.1 (1.1‐1.2) | <0.001 |
| Other | 1.1 (1.0‐1.1) | 0.006 | 1.1 (1.0‐1.1) | <0.001 | 1.0 (0.9‐1.1) | 0.994 | 1.0 (0.9‐1.1) | 0.725 |
| LCC | 1.4 (1.3‐1.5) | <0.001 | 1.4 (1.3‐1.5) | <0.001 | 1.3 (1.2‐1.4) | <0.001 | 1.3 (1.2‐1.4) | <0.001 |
| Unspecified | 1.4 (1.4‐1.4) | <0.001 | 1.4 (1.4‐1.4) | <0.001 | 1.2 (1.2‐1.2) | <0.001 | 1.2 (1.2‐1.2) | <0.001 |
| Grade (1 as ref.) | ||||||||
| 2 | 1.3 (1.2‐1.4) | <0.001 | 1.3 (1.2‐1.4) | <0.001 | 1.3 (1.2‐1.4) | <0.001 | 1.3 (1.2‐1.4) | <0.001 |
| 3 | 1.7 (1.5‐1.8) | <0.001 | 1.7 (1.6‐1.8) | <0.001 | 1.6 (1.5‐1.7) | <0.001 | 1.6 (1.5‐1.7) | <0.001 |
| 4 | 1.9 (1.7‐2.1) | <0.001 | 2.0 (1.8‐2.2) | <0.001 | 1.7 (1.5‐1.9) | <0.001 | 1.8 (1.6‐2.0) | <0.001 |
| Unknown | 1.6 (1.5‐1.8) | <0.001 | 1.7 (1.5‐1.8) | <0.001 | 1.5 (1.4‐1.6) | <0.001 | 1.5 (1.4‐1.7) | <0.001 |
| Number of distant metastasis (0 as ref.)b | ||||||||
| 1 | 1.1 (1.0‐1.1) | <0.001 | 1.1 (1.1‐1.1) | <0.001 | 1.1 (1.1‐1.1) | <0.001 | 1.2 (1.1‐1.2) | <0.001 |
| 2 | 1.3 (1.3‐1.4) | <0.001 | 1.4 (1.3‐1.4) | <0.001 | 1.5 (1.5‐1.6) | <0.001 | 1.6 (1.5‐1.6) | <0.001 |
| 3 | 1.6 (1.5‐1.6) | <0.001 | 1.6 (1.6‐1.7) | <0.001 | 1.9 (1.8‐1.9) | <0.001 | 1.9 (1.9‐2.0) | <0.001 |
| 4 | 1.5 (1.4‐1.7) | <0.001 | 1.6 (1.5‐1.8) | <0.001 | 1.8 (1.7‐2.1) | <0.001 | 2.0 (1.8‐2.2) | <0.001 |
| Chemotherapy (No as ref.) | 0.42 (0.41‐0.43) | <0.001 | 0.43 (0.42‐0.44) | <0.001 | 0.42 (0.41‐0.43) | <0.001 | 0.43 (0.42‐0.44) | <0.001 |
| Surgery (No as ref.) | 0.45 (0.42‐0.48) | <0.001 | 0.44 (0.41‐0.47) | <0.001 | 0.49 (0.45‐0.52) | <0.001 | 0.48 (0.45‐0.51) | <0.001 |
| Radiotherapy (No as ref.) | 0.87 (0.85‐0.89) | <0.001 | 0.89 (0.87‐0.91) | <0.001 | 0.89 (0.87‐0.90) | <0.001 | 0.90 (0.88‐0.92) | <0.001 |
n, number of cases/controls; OS, overall survival; CSS, cancer‐specific survival; PSM, propensity score matching; RT, radiotherapy; AD, adenocarcinoma; SQC, squamous cell carcinoma; Other, other specified carcinoma; LCC, large cell carcinoma; Unspecified, unspecified malignant neoplasm; HR, hazard ratio; CI, confidence interval.
a
Derived from COX regression analysis.
All the variables selected in this table were included in the multivariate analysis.
b
Number of distant metastasis included four sites of distant metastasis at diagnose SEER provided: bone, brain, liver, and lung.