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Positive predictive value (PPV) and sensitivity (SENS) for tumor/normal sequencing depth. Virtual tumor experiment PPV (solid line) and SENS (dotted line) percentages for single nucleotide variant callers MuTect (version 1.1.7) (black lines) and Strelka (version 1.0.14) (red lines) over a range of tumor/normal sequencing coverage. PPV increases with increased normal sequencing depth. SENS increases with increased tumor sequencing depth.
