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. 2018 Jul;15(7):504–512. doi: 10.11909/j.issn.1671-5411.2018.07.007

Table 2. Specific indications and adverse effects of different drugs used in the management of acute hypertension in the elderly.

Medication Specific Indications Adverse Effects
Nitroglycerin Acute coronary syndrome, pulmonary edema, volume overload Headache, vomiting reflex tachycardia and methemoglobinemia
Nitroprusside Use only in the elderly when other alternatives are not available Thiocyanate and cyanide intoxication, coronary steal syndrome
Nifedipine Not recommended in the elderly patient Hypotension, coronary steal syndrome, reflex tachycardia
Nicardipine Most hypertensive crises as a potent vasodilator Headache, local phlebitis, vomiting
Clevidipine Most hypertensive crises Headache, tachycardia, heart failure
Labetalol Acute aortic dissection Heart block and bronchoconstriction
Esmolol Post-operative hypertension, useful in increased cardiac output, easily titration Heart block and heart failure
Clonidine Severe hypertension associated with pain and anxiety Rebound hypertension and sedative effects
Fenoldopam Renal arterial disease, glomerulonephritis or vascular diseases with impaired renal function, very useful Headache, tachycardia, nausea and exacerbation of glaucoma
Hydralazine Not recommended in elderly patients Reflex tachycardia and severe hypotension