Table 3.
Cox regression analysis for overall survival
| Variables |
Univariate |
Multivariate |
||||
| HR | 95%CI | P | HR | 95%CI | P | |
| Gender | ||||||
| Female/male | 1.018 | 0.519-1.997 | 0.958 | |||
| Age | ||||||
| ≤ 60/> 60 | 1.175 | 0.548-2.518 | 0.679 | |||
| Pre-CEA | ||||||
| ≤ 5/> 5 | 1.067 | 0.496-2.298 | 0.868 | |||
| Pre-Hb | ||||||
| ≤ 120/> 20 | 0.651 | 0.328-1.290 | 0.219 | |||
| Distance to verge (cm) | ||||||
| ≤ 5/> 5 | 1.265 | 0.642-2.491 | 0.497 | |||
| T stage | ||||||
| T1 + T2/T3 + T4 | 4.221 | 1.011-17.632 | 0.048 | 4.05 | 0.968-116.93 | 0.055 |
| Lymph node metastasis | ||||||
| Negative/positive | 6.247 | 1.905-20.491 | 0.003 | 3.042 | 1.137-8.142 | 0.027 |
| Tumor thrombus | ||||||
| Negative/positive | 1.303 | 0.458-3.705 | 0.62 | |||
| Tumor differentiation | ||||||
| Poorly/moderately-well | 0.503 | 0.251-1.006 | 0.052 | - | - | 0.18 |
| Chemotherapy | ||||||
| No/yes | 1.407 | 0.430-4.605 | 0.572 | |||
| TUBB3 expression | ||||||
| Low/high | 2.407 | 1.188-4.877 | 0.015 | - | - | 0.1 |
| VEGFR1 expression | ||||||
| Low/high | 2.817 | 1.424-5.570 | 0.003 | 2.151 | 1.062-4.355 | 0.033 |
Pre-CEA: Preoperative carcino-embryonic antigen; Pre-Hb: Preoperative hemoglobin.