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. 2018 Aug 21;67(11):2206–2212. doi: 10.2337/db18-0308

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© 2018 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.

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p66ShcKO restored renal microvascular responses in diabetic rats. A: Comparison of afferent arteriole diameters in SS, p66ShcKO, and p66Shc-S36A rats before and after induction of STZ-induced DN. ^#P < 0.05 vs. SS rats; *P < 0.01 vs. STZ-treated SS rats. B: Effect of pinacidil. Pinacidil resulted in a greater increase in afferent arteriolar diameter in SS rats with STZ-induced DN than in p66ShcKO rats with STZ-induced diabetes and p66Shc-S36A rats with STZ-induced diabetes. Values in untreated SS rats, p66ShcKO rats, and p66Shc-S36A rats are also shown. C: Effect of glibenclamide. Glibenclamide resulted in a greater decrease in afferent arteriolar diameter in SS rats with STZ-induced DN than in p66ShcKO rats with STZ-induced diabetes and p66Shc-S36A rats with STZ-induced diabetes. Values in untreated SS rats, p66ShcKO rats, and p66Shc-S36A rats are also shown. For panels B and C, *P < 0.01 vs. SS rats; ^†P < 0.05 vs. STZ-treated SS rats.