Fig. 1.

a-f Scatterplots depicting the relationship between predicted and chronological age in 6 represented models from our cross validation testing. g Box and whisker plots of the R2 values (predicted vs. actual) for the training data set from each cross validation for all four potential model designs including the CpG level training across the entire array and only those within the age-affected regions, as well as the full regional data set (148 regions) and the optimized regional data set (51 regions). h Box and whisker plots of the R2 values (predicted vs. actual) for the test data set from each cross validation for all four potential model designs including the CpG level training across the entire array and only those within the age-affected regions, as well as the full regional data set (148 regions) and the optimized regional data set (51 regions)