Table 3.
Bone outcomes at baseline, 6- and 12-months of those participants who completed the study (n = 13). Values are mean (standard deviation) at baseline and 6- and 12-months and adjusted mean change (95% confidence interval) from baseline to 6-months and 12-months
| Variable | Baseline | 6-months | 12-months | Baseline – 6-months changed | Baseline – 12-months changed |
|---|---|---|---|---|---|
| LS BMC (g) | 32.6 (8.4) | 35.0 (8.3) | 37.0 (9.1) | 0.3 (− 0.9, 1.6) | 1.2 (− 0.5, 2.8) |
| LS BMC z-score | −0.09 (0.64) | − 0.14 (0.65) | − 0.14 (0.65) | − 0.04 (− 0.24, 0.16) | −0.02 (− 0.28, 0.23) |
| Distal tibia Tt.BMD (mg/cm3) | 223.1 (34.1) | 223.8 (28.7) | 234.9 (29.5) | 2.7 (−5.0, 10.5) | 15.0 (5.0, 25.0)a |
| z-score | − 0.98 (1.73) | − 1.10 (1.47) | − 0.86 (1.60) | − 0.15 (− 0.44, 0.13) | 0.06 (− 0.30, 0.43) |
| # with z-score < − 2 | 3 | 2 | 3 | ||
| Distal tibia BV/TV | 0.141 (0.026) | 0.141 (0.022) | 0.144 (0.026) | −0.001 (− 0.006, 0.004) | 0.001 (− 0.005, 0.007) |
| z-score | − 0.74 (1.48) | − 0.79 (1.30) | − 0.69 (1.46) | − 0.08 (− 0.31, 0.15) | 0.01 (− 0.29, 0.30) |
| # with z-score < − 2 | 4 | 3 | 3 | ||
| Distal tibia Ct.Th (mm) | 0.69 (0.15) | 0.69 (0.17) | 0.77 (0.14) | −0.002 (− 0.054, 0.050) | 0.075 (0.009, 0.142)b |
| z-score | −1.35 (1.62) | − 1.65 (1.59) | − 1.08 (1.62) | − 0.62 (− 1.14, − 0.10)d | −0.23 (− 0.91, 0.44) |
| # with z-score < − 2 | 4 | 4 | 2 | ||
| Distal tibia F.Load (N) | 3628 (845) | 3825 (771) | 4121 (878) | 4.8 (− 204.9, 214.6) | 190.2 (−81.1, 461.5) |
| z-score | −1.57 (1.58) | − 1.58 (1.14) | − 1.33 (1.39) | −0.08 (− 0.40, 0.25) | 0.13 (− 0.29, 0.55) |
| # with z-score < − 2 | 4 | 4 | 4 | ||
| Distal radius Tt.BMD (mg/cm3)c | 251.3 (37.7) | 245.5 (29.4) | 242.3 (33.8) | −0.5 (− 14.2, 13.1) | 1.5 (− 16.6, 19.6) |
| z-score | 0.07 (0.83) | −0.26 (0.99) | − 0.47 (0.90) | − 0.42 (− 0.80, − 0.03)d | −0.60 (− 1.11, − 0.09)b |
| # with z-score < − 2 | 0 | 0 | 0 | ||
| Distal radius BV/TVc | 0.136 (0.022) | 0.139 (0.023) | 0.135 (0.027) | 0.002 (−0.004, 0.007) | − 0.004 (− 0.011, 0.004) |
| z-score | −0.50 (0.97) | − 0.42 (1.01) | −0.67 (1.32) | 0.01 (− 0.27, 0.30) | −0.27 (− 0.64, 0.10) |
| # with z-score < − 2 | 1 | 1 | 1 | ||
| Distal radius Ct.Th (mm)c | 0.62 (0.15) | 0.60 (0.13) | 0.60 (0.16) | 0.03 (−0.03, 0.10) | 0.08 (− 0.01, 0.16) |
| z-score | −0.21 (1.01) | − 0.61 (0.98) | −0.77 (0.83) | − 0.36 (− 0.97, 0.24) | −0.39 (− 1.18, 0.40) |
| # with z-score < − 2 | 0 | 1 | 0 | ||
| Distal radius F.Load (N)c | 1217 (392) | 1297 (393) | 1301 (375) | 27.6 (−43.7, 99.0) | − 10.2 (− 105.3, 84.8) |
| z-score | −0.93 (1.47) | − 1.02 (1.32) | −1.25 (1.37) | − 0.22 (− 0.55, 0.12) | −0.38 (− 0.83, 0.06) |
| # with z-score < − 2 | 3 | 2 | 3 |
BMC bone mineral content, Tt.BMD total bone mineral density, BV/TV trabecular bone volume ratio, Ct.Th cortical thickness, F.Load failure load
ap < 0.01; bp < 0.05
cn = 12 at baseline and 6-months and n = 11 at 12-months
d Adjusted for change in height and maturity offset at baseline