Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Oct 21;17:1533033818806910. doi: 10.1177/1533033818806910

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

PMC Copyright notice

Figure 3. — Possible therapeutic strategies for cancer stem cell elimination. (1) Targeting surface protein biomarkers such as CD133 with the aim to develop CSC-specific therapies. (2) Inhibiting the role of efflux transporters to reduce resistance to cancer drugs. (3) Reprogramming CSCs to a normal state by altering their metabolism and inducing them to differentiate. (4) Inhibiting pathways essential for CSC proliferation such as the Wnt/β-catenin signaling pathway. (5) Affecting the vascular niche to impair microenvironmental mechanisms that regulate GSC maintenance and function. CSC indicates cancer stem cell; GSC, germinal stem cell.