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. 2018 Oct 22;18:168. doi: 10.1186/s12935-018-0657-1

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Effects of a forced reversal of the PON3 levels on the drug resistance of K510 cells. The levels of PON3 mRNA (a) and protein level (b) determined by qRT-PCR and western blot analysis in the eight esophageal cancer cell lines. The levels of protein level (c) PON3 and mRNA (d) determined by western blot and qRT-PCR analysis in the si-PON3-transfected versus the NC-transfected K510. The cell death triggered by an IC₅₀ dose of four drugs in K510 cells transfected with the si-PON3-transfected versus the negative control (NC) assayed 72 h after treatment with the IC₅₀ dose of drugs (e)