Nasal airspace and cartilage changes in Fgfr2 mutant mice. (A) Anterior, (B) midnasal and (C) posterior nasal space area measurements. (D) Anterior, (E) midnasal and (F) posterior total cartilage area measurements. S252W, Apert Fgfr2+/S252W; P253R, Apert Fgfr2+/P253R; CZ, Crouzon Fgfr2C342Y/+. Blue boxes, unaffected littermates (Fgfr2+/+; WT); red boxes, mutant. n=4-15. Data are presented as the median, 25th and 75th percentiles; whiskers indicate minimum and maximum values. *P<0.05 (Student's t-test).