Fig. 1.

ML consensus phylogenetic tree of 149 M. tuberculosis Ural family strains (CAS family strain was used as outgroup) based on 6002 genome-wide variable amino acid positions. Strain designation includes consecutive number (Additional file 1: Table S1), country of origin, drug resistance. Abbreviations: RU – Russia, MD – Moldova, BY – Belarus, MDR – multidrug resistance, H – isoniazid resistant, E – ethambutol resistant, S – streptomycin resistant, P - pyrazinamide resistant, sus – susceptible, # - pre-XDR, ## - XDR. *- genotypic resistance profile confirmed by phenotypic data (when available at GMTV database http://mtb.dobzhanskycenter.org/). The CAS strain was used as outgroup under phylogenetic analysis; it did not have any drug resistance mutation