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. 2018 Oct 22;17:153. doi: 10.1186/s12943-018-0896-8

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Overexpression of G9a in NSCLC. Box-and-Whisker plot of G9a mRNA expression in a lung adenocarcinoma (LUAD), b lung squamous carcinoma (LUSC). Box represents first and third quartiles, thick band is median value, and bars extend to ± the interquartile range divided by the square root of the number of samples) were applied to describe G9a gene expression values. Compared to normal lung tissues (Gr1, n = 59/46), G9a mRNA was significantly increased in LUAD/LUSC (Gr2, n = 517/494) (fold change/FC = 1.7, and P = 4.52E-24/6.89E-17). c Photomicrographs of G9a in normal lung tissue. d Photomicrographs of G9a in four representative lung adenocarcinoma sections scored as 0 to 3+ (magnification, × 200; red bar, 60 μm)