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. 2018 Oct 22;17:153. doi: 10.1186/s12943-018-0896-8

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Changes of gene expression profile and gene set in NSCLC cells upon knockdown of G9a. a Unsupervised hierarchical clustering analysis of global expression profiles in A549 and H1299 cells upon G9a knockdown. The two top rows represent two independent siRNA repeats, C1/2 is for control siRNA and G1/2 is for specific siRNA1/2 for G9a. b qRT–PCR, c Western blot analysis for selected genes in A549, H1299, and H1975 cells. The level of each gene in cancer cell transfected with G9a siRNA is the average ratio of triplicates of two repeated experiments, and is presented as the ratio to control sample transfected with scramble siRNA (* P < 0.05, compared to control cells transfected with scramble siRNA). d Selected gene sets that were enriched upon G9a knockdown in these lung cancer cells