Table 2.
Non-GFR Factors Affecting Creatinine Levels in Children (Modified From Mian AN, Schwartz GJ. Tests of Kidney Function in Children. In: Fuhrman BP, Zimmerman JJ, eds. Fuhrman and Zimmerman’s Pediatric Critical Care. Fifth ed. 2017:1026-1039)76
| Factor | The Estimated GFR Level
|
|
|---|---|---|
| Increase | Decrease | |
| Affecting creatinine generation | Age (infancy through adolescence) | Chronic illness, anorexia, malnutrition, neuromuscular disease, liver disease |
| Male gender (after puberty) | Body habitus (amputation) | |
| Body habitus (muscular) | Diet (vegetarian) | |
| Weight lifting | ||
| Diet: consumption of cooked meat | ||
| Creatine supplements | ||
| Affecting creatinine elimination | Impaired tubular secretion (trimethoprim, cimetidine) | Tubular secretion |
| Impaired extrarenal elimination (sterilization of gastrointestinal flora by antibiotics) | Extrarenal elimination (gastrointestinal degradation) | |
Abbreviation: GFR, glomerular filtration rate.