Table 3.
Associations of miR-146a C>G, miR-196a2 T>C, miR-499 A>G, and miR-149 T>C polymorphisms between IS risk and control groups.
| Genotypes | Control (n,%) | IS (n,%) | OR (95% CI) | P | ||||
|---|---|---|---|---|---|---|---|---|
| miR-146a (C>G) | ||||||||
| CC | 154 (40.7) | 131 (33.1) | 1 | |||||
| CG | 179 (47.4) | 194 (49) | 1.27 (0.94, 1.74) | 0.125 | ||||
| GG | 45 (11.9) | 71 (17.9) | 1.86 (1.19, 2.88) | 0.006 | ||||
| CC vs. (CGG) | 1.39 (1.04, 1.86) | 0.027 | ||||||
| (CC+CG) vs. GG | 1.62 (1.08, 2.42) | 0.020 | ||||||
| CC vs. CG vs. GG | 1.34 (1.09, 1.65) | 0.006 | ||||||
| C | 487 (64.4) | 456 (57.6) | 1 | |||||
| G | 269 (35.6) | 336 (42.4) | 1.33 (1.09, 1.64) | 0.006 | ||||
| miR-196a2 (T>C) | ||||||||
| TT | 110 (29.1) | 112 (28.3) | 1 | |||||
| TC | 196 (51.9) | 205 (51.8) | 1.03 (0.74, 1.43) | 0.872 | ||||
| CC | 72 (19) | 79 (19.9) | 1.08 (0.71, 1.63) | 0.723 | ||||
| TT vs. (TC+CC) | 1.04 (0.76, 1.42) | 0.801 | ||||||
| (TT+TC) vs. CC | 1.06 (0.74, 1.51) | 0.752 | ||||||
| TT vs. TC vs. CC | 1.04 (0.85, 1.27) | 0.728 | ||||||
| T | 416 (55) | 429 (54.2) | 1 | |||||
| C | 340 (45) | 363 (45.8) | 1.04 (0.85, 1.27) | 0.734 | ||||
| miR-499 (A>G) | ||||||||
| AA | 249 (65.9) | 255 (64.4) | 1 | |||||
| AG | 116 (30.7) | 123 (31.1) | 1.04 (0.76, 1.41) | 0.825 | ||||
| GG | 13 (3.4) | 18 (4.5) | 1.35 (0.65, 2.82) | 0.421 | ||||
| AA vs. (AG+GG) | 1.07 (0.79, 1.44) | 0.666 | ||||||
| (AA+AG) vs. GG | 1.34 (0.65, 2.77) | 0.434 | ||||||
| AA vs. AG vs. GG | 1.09 (0.85, 1.39) | 0.524 | ||||||
| A | 614 (81.2) | 633 (79.9) | 1 | |||||
| G | 142 (18.8) | 159 (20.1) | 1.09 (0.84, 1.4) | 0.521 | ||||
| miR-149 (T>C) | ||||||||
| TT | 190 (50.3) | 165 (41.7) | 1 | |||||
| TC | 158 (41.8) | 179 (45.2) | 1.31 (0.97, 1.76) | 0.081 | ||||
| CC | 30 (7.9) | 52 (13.1) | 2.00 (1.22, 3.28) | 0.006 | ||||
| TT vs. (TC+CC) | 1.42 (1.07, 1.88) | 0.017 | ||||||
| (TT+TC) vs. CC | 1.75 (1.09, 2.82) | 0.020 | ||||||
| TT vs. TC vs. CC | 1.37 (1.11, 1.7) | 0.004 | ||||||
| T | 538 (71.2) | 509 (64.3) | 1 | |||||
| C | 218 (28.8) | 283 (35.7) | 1.37 (1.11, 1.7) | 0.004 | ||||
OR – adjusted odds ratio; 95% CI – 95% confidence interval. OR based on the risk factors, including age, sex, hypertension, diabetes, BMI, smoking, drinking, TC, TG, LDL-c, and HDL-c.