Table 4.
Associations of miR-146a C>G, miR-196a2 T>C, miR-499 A>G, and miR-149 T>C polymorphisms between the subgroups and the control group.
| Genotypes | Control n (%) | LAA | SAO | ||||
|---|---|---|---|---|---|---|---|
| n (%) | OR (95% CI) | P | n (%) | OR (95% CI) | P | ||
| miR-146a (C>G) | |||||||
| CC | 154 (40.7) | 84 (31.3) | 1 | 47 (36.7) | 1 | ||
| CG | 179 (47.4) | 134 (50) | 1.37 (0.97, 1.94) | 0.074 | 60 (46.9) | 1.1 (0.71, 1.7) | 0.675 |
| GG | 45 (11.9) | 50 (18.7) | 2.04 (1.26, 3.3) | 0.004 | 21 (16.4) | 1.53 (0.83, 2.82) | 0.174 |
| CC vs. (CG+GG) | 1.51 (1.08, 2.09) | 0.015 | 1.19 (0.78, 1.79) | 0.422 | |||
| (CC+CG) vs. GG | 1.7 (1.1, 2.63) | 0.018 | 1.45 (0.83, 2.55) | 0.193 | |||
| CC vs. CG vs. GG | 1.41 (1.09, 1.82) | 0.008 | 1.2 (0.9, 1.62) | 0.218 | |||
| C | 487 (64.4) | 302 (56.3) | 1 | 154 (60.2) | 1 | ||
| G | 269 (35.6) | 234 (43.7) | 1.4 (1.12, 1.76) | 0.003 | 102 (39.8) | 1.2 (0.9, 1.6) | 0.222 |
| miR-196a2 (T>C) | |||||||
| TT | 110 (29.1) | 75 (28) | 1 | 37 (28.9) | 1 | ||
| TC | 196 (51.9) | 139 (51.9) | 1.04 (0.72, 1.5) | 0.833 | 66 (51.6) | 1 (0.63, 1.59) | 0.996 |
| CC | 72 (19) | 54 (20.1) | 1.1 (0.7, 1.74) | 0.684 | 25 (19.5) | 1.03 (0.57, 1.86) | 0.916 |
| TT vs. (TC+CC) | 1.06 (0.75, 1.49) | 1.01 (0.65, 1.57) | 0.967 | ||||
| (TT+TC) vs. CC | 1.07 (0.72, 1.59) | 0.728 | 1.03 (0.62, 1.71) | 0.904 | |||
| TT vs. TC vs. CC | 1.05 (0.84, 1.32) | 0.686 | 1.01 (0.76, 1.36) | 0.923 | |||
| T | 416 (55) | 289 (53.9) | 1 | 140 (54.7) | 1 | ||
| C | 340 (45) | 247 (46.1) | 1.05 (0.84, 1.31) | 0.693 | 116 (45.3) | 1.01 (0.76, 1.35) | 0.925 |
| miR-499 (A>G) | |||||||
| AA | 249 (65.9) | 172 (64.2) | 1 | 83 (64.8) | 1 | ||
| AG | 116 (30.7) | 83 (30.9) | 1.04 (0.74, 1.46) | 0.84 | 40 (31.2) | 1.03 (0.67, 1.6) | 0.879 |
| GG | 13 (3.4) | 13 (4.9) | 1.45 (0.66, 3.2) | 0.36 | 5 (3.9) | 1.15 (0.4, 3.33) | 0.791 |
| AA vs. (AG+GG) | 1.08 (0.78, 1.5) | 0.656 | 1.05 (0.69, 1.59) | 0.832 | |||
| (AA+AG) vs. GG | 1.43 (0.65, 3.14) | 0.371 | 1.14 (0.4, 3.27) | 0.805 | |||
| AA vs. AG vs. GG | 1.1 (0.84, 1.45) | 0.491 | 1.05 (0.73, 1.5) | 0.792 | |||
| A | 614 (81.2) | 427 (79.7) | 1 | 206 (80.5) | 1 | ||
| G | 142 (18.8) | 109 (20.3) | 1.1 (0.84, 1.46) | 0.487 | 50 (19.5) | 1.05 (0.73, 1.5) | 0.792 |
| miR-149 (T>C) | |||||||
| TT | 190 (50.3) | 100 (37.3) | 1 | 65 (50.8) | 1 | ||
| TC | 158 (41.8) | 129 (48.1) | 1.55 (1.11, 2.17) | 0.010 | 50 (39.1) | 0.93 (0.61, 1.42) | 0.719 |
| CC | 30 (7.9) | 39 (14.6) | 2.47 (1.45, 4.21) | 0.001 | 13 (10.2) | 1.27 (0.62, 2.57) | 0.514 |
| TT vs. (TC+CC) | 1.7 (1.23, 2.34) | 0.001 | 0.98 (0.66, 1.46) | 0.92 | |||
| (TT+TC) vs. CC | 1.98 (1.19, 3.27) | 0.008 | 1.31 (0.66, 2.6) | 0.437 | |||
| TT vs. TC vs. CC | 1.57 (1.23, 1.99) | <0.001 | 1.04 (0.76, 1.42) | 0.796 | |||
| T | 538 (71.2) | 329 (61.4) | 1 | 180 (70.3) | 1 | ||
| C | 218 (28.8) | 207 (38.6) | 1.55 (1.23, 1.96) | <0.001 | 76 (29.7) | 1.04 (0.76, 1.42) | 0.795 |
OR – adjusted odds ratio; 95% CI – 95% confidence interval. OR based on the risk factors, including age, sex, hypertension, diabetes, BMI, smoking, drinking, TC, TG, LDL-c, and HDL-c.