. 2018 Jul 20;114(13):1702–1713. doi: 10.1093/cvr/cvy174

Table 1.

Experimental models used to study aneurysm development in diabetic mice

Diabetes model	Aneurysm model	Main results	References
T1D: streptozotocin administration	CaPO₄-induced aneurysm in the carotid artery of C57BL/6 mice	Decreased AAA formation	Tanaka et al.³⁶
		Decreased macrophage infiltration	Tanaka et al.³⁶
	Elastase infusion in the abdominal aorta of C57BL/6 mice	Decreased AAA formation	Dua et al.³⁴
		Decreased macrophage infiltration associated with decreased PAI-1 aortic gene expression	Dua et al.³⁴
		Decreased AAA formation	Miyama et al.³⁵
		Decreased macrophage infiltration associated with a decrease of mural neovascularity and MMP9 activity and a better elastin preservation	Miyama et al.³⁵
	Angiotensin II infusion in ApoE^−/− mice	Decreased AAA formation	Miyama et al.³⁵
	Angiotensin II infusion in ApoE^−/− mice	Better elastin preservation	Miyama et al.³⁵
	Angiotensin II infusion in CDA1/ ApoE^−/− mice	Development of AAA in diabetic CDA1/ ApoE^−/− mice, not observed in diabetic ApoE^−/− or diabetic wild type mice	Li et al.³⁷
	Angiotensin II infusion in CDA1/ ApoE^−/− mice	Increased macrophage infiltration and MMP12 expression, reduced collagen expression and TGF-β signalling in diabetic CDA1/ ApoE^−/− mice	Li et al.³⁷
T2D: KK-Ay mice	CaPO₄-induced aneurysm in the carotid artery	Decreased aneurysm formation	Tanaka et al.³⁶
T2D: KK-Ay mice	CaPO₄-induced aneurysm in the carotid artery	Decreased macrophage infiltration	Tanaka et al.³⁶