Table 1.
MICs for clinical strains and isogenic mutant strains
| Species | Strain | Characteristic | MIC (mg/L) |
|||||
|---|---|---|---|---|---|---|---|---|
| cefiderocol | ceftazidime | cefepime | imipenem | meropenem | aztreonam | |||
| P. aeruginosa | PAO1 | 0.125 | 1 | 1 | 1 | 0.5 | 4 | |
| P. aeruginosa | PW8615 | ΔampD (Tn) | 0.25 | 16 | 4 | 1 | 1 | 8 |
| P. aeruginosa | PW6111 | ΔdacB (Tn) | 0.25 | 16 | 8 | 1 | 0.5 | 16 |
| P. aeruginosa | PW7953 | ΔampC (Tn) | 0.063 | 1 | 2 | 0.125 | 0.5 | 2 |
| P. aeruginosa | SR24 | 0.125 | 1 | 1 | 1 | 0.063 | 4 | |
| P. aeruginosa | SR24-12 | AmpC high producer | 0.125 | >32 | 16 | 0.5 | 0.125 | >32 |
| E. cloacae | 1480700 | 0.25 | 0.5 | 0.063 | 0.5 | 0.063 | 0.125 | |
| E. cloacae | 1480700-4 | AmpC high producer | 1 | 32 | 1 | 0.5 | 0.063 | 32 |
Tn, transposon insertion.
MICs were determined by the broth microdilution method using ID-CAMHB for cefiderocol and CAMHB for the other antibiotics.