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. Author manuscript; available in PMC: 2018 Oct 23.
Published in final edited form as: Eur J Hum Genet. 1997 Jan-Feb;5(1):9–14.

Fig. 3.

Fig. 3.

Integrated genetic and physical map and YAC contig comprising the cystinosis critical region. Shown on top (A) is the known genetic order, from telomere (left) to centromere (right) of the markers D17S1583, D17S1798, D17S1828, and D17S1584 and the refined genetic order as derived from recombination events observed in this study (B). Note that the order of D17S1583 and D17S1798 has been retained as reported in Jean et al. [2] and thus differs from the recently published genetic map [8]. YAC clones are positioned according to their STS content as indicated by hatched symbols with squares for the polymorphic STSs contained in the genetic map and round symbols for the non-polymorphic markers D17S2027 (WI9827) and JD17S2054 (WI7337). The position of these non-polymorphic markers within the framework of genetic markers is indicated in C, which represents the integrated genetic and physical map of the region. The hatched area shows where the cystinosis locus is situated on the basis of recombination events reported in the literature [1,2] and in this study.