Table 1.

Donor suitability of individuals who are heterozygous for a mutation in COL4A3 or COL4A4 based on the phenotype of the mutation in the heterozygous state

Genotype–phenotype correlation	Risk of CKD/ESRD	Suitability for donation
Mutation in heterozygous state is associated with CKD/ESRD, in family or in mutation databases	High	Not suitable for donation
Mutation in heterozygous state is associated with isolated hematuria	Low	May be suitable if no other donors available
Mutation in heterozygous state is asymptomatic	Low	May be suitable if no other donors available

Abbreviations: CKD, chronic kidney disease; ESRD, end-stage renal disease.