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Effect of CYP2C9 and VKORC1 on mean dose (mg/week), according to genotype and sensitivity group
| Gene | Genotype | Mean dose (mg/week) | P-value | |
|---|---|---|---|---|
|
| ||||
| VKORCI | GG | 39.33 (mg/week) | 0.0001 | |
| AA | 22.95 (mg/week) | |||
| CYP2C9 | *l/*l | 33.14 (mg/week) | 0.001 | |
| *2/*2 *2/*3 | 20 (mg/week) | |||
|
| ||||
| Sensitivity groups | Mean dose (mg/week) | P-value | Adverse drug reactions | P-value |
|
| ||||
| Normal (n=104) | 35.53 (mg/week) | 0.001 | 35.6% (n=37) | 0.002 |
| Moderate (n=44) | 25.21 (mg/week) | 65.9% (n=29) | ||
| High (n=4) | 15.6 (mg/week) | 75% (n=3) | ||
