Table 2. Results of the multiple variables Cox’s regression analysis.

ARR: annualized relapse rate; ARR-MRI: annualized MRI relapse rate; HR: hazard ratio; SE: standard error; 95%CI: 95% confidence interval.

	HR	SE	z	p	95%CI
Age	1.04	0.017	2.30	0.022	1.006	1.073
Gender (F)	0.56	0.200	-1.62	0.105	0.277	1.128
Clinical relapses	1.14	0.283	0.53	0.596	0.701	1.854
ARR	2.03	0.965	1.49	0.135	0.801	5.154
MRI relapses	0.80	0.472	-0.38	0.701	0.250	2.542
ARR-MRI	0.89	0.535	-0.20	0.843	0.272	2.896
First line treatment	1.37	0.592	0.73	0.463	0.589	3.195
Second line treatment	1.56	1.271	0.54	0.589	0.314	7.716
Third line treatment	3.60	2.170	2.12	0.034	1.104	11.731
BDNF gene polymorphism (Met+)	0.74	0.439	-0.51	0.613	0.232	2.366
BDNF gene methylation (<81%)	2.72	1.382	1.97	0.049	1.005	7.365
Polymorphism X Methylation	2.36	1.890	1.07	0.283	0.491	11.339