Table 2. Hazard ratios for associations between sitting time, physical activity and total and specific cancer incidence.
| Sitting time (h/day) | Physical activity (MET-h/week) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Events/person-yrs | <8 | ≥8 | p-value | High (>16.6) | Moderate (8.4–16.6) | Low (≤8.3) | p-value for trend | |||
| Total cancer | ||||||||||
| Age-adjusted | ||||||||||
| Men | 2435/295342 | 1.00 (ref) | 1.07 (0.98, 1.18) | 0.11 | 1.00 (ref) | 1.01 (0.90, 1.13) | 1.08 (0.98, 1.20) | 0.12 | ||
| Women | 1761/312734 | 1.00 (ref) | 1.05 (0.94, 1.17) | 0.42 | 1.00 (ref) | 1.00 (0.86, 1.16) | 0.95 (0.83, 1.08) | 0.42 | ||
| Multivariate1 | ||||||||||
| Men | 2435/295342 | 1.00 (ref) | 1.08 (0.98, 1.18) | 0.11 | 1.00 (ref) | 1.00 (0.89, 1.12) | 1.06 (0.95, 1.17) | 0.30 | ||
| Women | 1761/312734 | 1.00 (ref) | 1.02 (0.91, 1.14) | 0.78 | 1.00 (ref) | 1.00 (0.86, 1.16) | 0.95 (0.83, 1.09) | 0.47 | ||
| Colorectal cancer | ||||||||||
| Age-adjusted | ||||||||||
| Men | 388/305186 | 1.00 (ref) | 1.16 (0.93, 1.45) | 0.18 | 1.00 (ref) | 1.23 (0.92, 1.65) | 1.29 (1.00, 1.68) | 0.05 | ||
| Women | 255/321504 | 1.00 (ref) | 1.00 (0.74, 1.36) | 0.99 | 1.00 (ref) | 1.05 (0.72, 1.53) | 0.83 (0.58, 1.18) | 0.29 | ||
| Multivariate1 | ||||||||||
| Men | 388/305186 | 1.00 (ref) | 1.14 (0.91, 1.43) | 0.26 | 1.00 (ref) | 1.26 (0.94, 1.69) | 1.31 (1.00, 1.70) | 0.05 | ||
| Women | 255/321504 | 1.00 (ref) | 1.02 (0.75, 1.39) | 0.91 | 1.00 (ref) | 1.05 (0.72, 1.54) | 0.82 (0.57, 1.18) | 0.29 | ||
| Prostate cancer (men) | ||||||||||
| Age-adjusted | 889/304927 | 1.00 (ref) | 1.32 (1.14, 1.53) | 0.00 | 1.00 (ref) | 0.78 (0.65, 0.93) | 0.94 (0.80, 1.11) | 0.47 | ||
| Multivariate1 | 889/304927 | 1.00 (ref) | 1.22 (1.05, 1.42) | 0.01 | 1.00 (ref) | 0.83 (0.68, 0.99) | 1.01 (0.86, 1.19) | 0.87 | ||
| Lung cancer | ||||||||||
| Age-adjusted | ||||||||||
| Men | 242/306817 | 1.00 (ref) | 1.02 (0.76, 1.36) | 0.90 | 1.00 (ref) | 1.54 (1.03, 2.29) | 1.82 (1.27, 2.61) | 0.00 | ||
| Women | 149/322643 | 1.00 (ref) | 0.82 (0.53, 1.25) | 0.35 | 1.00 (ref) | 0.93 (0.52, 1.64) | 1.22 (0.74, 2.03) | 0.44 | ||
| Multivariate1 | ||||||||||
| Men | 242/306817 | 1.00 (ref) | 1.14 (0.86, 1.54) | 0.36 | 1.00 (ref) | 1.27 (0.85, 1.90) | 1.45 (1.01, 2.09) | 0.04 | ||
| Women | 149/322643 | 1.00 (ref) | 0.85 (0.55, 1.31) | 0.46 | 1.00 (ref) | 0.77 (0.44, 1.38) | 0.95 (0.57, 1.59) | 0.84 | ||
| Breast cancer (women) | ||||||||||
| Age-adjusted | 513/319365 | 1.00 (ref) | 1.12 (0.91, 1.36) | 0.28 | 1.00 (ref) | 0.89 (0.68, 1.16) | 0.86 (0.68, 1.09) | 0.21 | ||
| Multivariate1 | 513/319365 | 1.00 (ref) | 1.04 (0.85, 1.27) | 0.74 | 1.00 (ref) | 0.92 (0.70, 1.19) | 0.93 (0.73, 1.17) | 0.52 | ||
1 Adjusted for age, education, smoking, alcohol, BMI