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. 2018 Oct 23;13(10):e0206246. doi: 10.1371/journal.pone.0206246

Table 2. Summary of ADC cytotoxicity assay.

Toxicity DM1-ADC MMAE-ADC
This Studya* Literature* This studya* Literature
IC50 (nM) 3.88 2.71–4.26a and 0.24b [25], 4.7a [43] 1.95 2.7–13.8c** [44], 0.60a** [45]
Viability (%) <10 50–60a and 30–35b [25], 40b [46] <10 5–15c** [19], 25a** [45]

Note: Cell lines:

aBT474,

bSK-BR-3, and

c Karpas 299;

assay timeline:

*3 days and

**4 days.