Table 2. Summary of ADC cytotoxicity assay.
Toxicity | DM1-ADC | MMAE-ADC | ||
---|---|---|---|---|
This Studya* | Literature* | This studya* | Literature | |
IC50 (nM) | 3.88 | 2.71–4.26a and 0.24b [25], 4.7a [43] | 1.95 | 2.7–13.8c** [44], 0.60a** [45] |
Viability (%) | <10 | 50–60a and 30–35b [25], 40b [46] | <10 | 5–15c** [19], 25a** [45] |
Note: Cell lines:
aBT474,
bSK-BR-3, and
c Karpas 299;
assay timeline:
*3 days and
**4 days.