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. 2018 Oct 11;14(10):e1007681. doi: 10.1371/journal.pgen.1007681

Fig 6. Network of CAD associated genes that may regulate HCASMC phenotype as a mechanism of disease risk.

Fig 6

Genes in red text reside in replicated CAD associated loci, with genomic and/or functional data supporting their causality [73, 75] [6, 7, 11, 21, 32–34, 56]. Gene symbols in ellipses indicate CAD associated transcription factors. HCASMC ChIPseq data presented here or previously published provide evidence of direct transcriptional regulation and RNAseq data provides evidence of directionality [34, 56]. These and other data reveal a pervasive role of the TGFβ pathway in CAD causality [10], and also suggest that linked TCF21 and PDGF signaling is an important component of disease risk.