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. 2018 Oct 12;13:6375–6390. doi: 10.2147/IJN.S180970

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© 2018 Obiweluozor et al. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Cell viability indices of combined therapy and the effect of treatment on cancer cells assessed by LIVE/DEAD^® assay with CT26 cancer cells.

Notes: (A) Histogram showing CCK-8 data (OD) of CT26 cancer cell viability for control and therapy groups with no irradiation on 1, 3, and 5 days. (B) The viability of CT26 colon cancer cell co-incubated with PDO, PDO+PD, and PDO+PD-BTZ. (C and D) LIVE/DEAD^® cell microscopic images of PDO+PD nanofiber after 72 hours of treatment. (E and F) Combined photothermal and chemotherapy treatment using PDO+PD-BTZ nanofiber after 72 hours of treatment. One-way ANOVA post hoc Tukey test was used to indicate the significance (^*P<0.05, ^**P<0.01, and ^***P<0.001).

Abbreviations: BTZ, bortezomib; PDO, polydioxanone; PD, polydopamine; TCP, tissue culture plate; OD, optical density; CCK-8, cell counting kit-8.