Table 2.
Comparison of the 2016–2017win, 2017sum and 2014 H3N2 virus strains with respect to the WHO recommended vaccine strains (A/Hong Kong/4801/2014)
| Virus strain | Protein | Amino acid position | Function or domain of mutation (references) | Proportion (%) | Mutations contained in the 2016–2017win isolates (2016–2017win02, 16, 21) | Mutations contained in the 2017sum isolates (2017sum10, 14, 18) | Mutations contained in the 2014 H3N2 virus strain |
|---|---|---|---|---|---|---|---|
| 2016–2017win | PB2 | R299K | 100 | +a | – | – | |
| PB1-F2 | R25Q | Pathogenesis associated motif35 | 100 | + | – | – | |
| H75P | 100 | + | – | – | |||
| PA | I668V | PB1 interaction domain24 | 95.8 | + | – | – | |
| PA-X | R15K | 100 | + | – | – | ||
| HA1 | T114S | HA stalk globular head36 | 100 | + | – | + | |
| T131K | 100 | + | – | – | |||
| I140T | 35.7 | – | – | – | |||
| R142K | 100 | + | – | – | |||
| R261Q | 100 | + | – | – | |||
| NS1 | N127S | PKR-binding domain26 | 100 | + | – | – | |
| 2017 sum | PB2 | K340R | 80.8 | – | + | – | |
| PB1-F2 | R25Q | Pathogenesis associated motif35 | 100 | – | + | – | |
| H75P | 100 | – | + | – | |||
| PA-X | R15K | 100 | – | + | – | ||
| HA1 | K92R | HA stalk globular head31 | 91.2 | – | + | – | |
| T114S | 91.2 | – | + | – | |||
| N121K | 100 | – | + | – | |||
| T135K | 47.1 | – | + | – | |||
| T135N | 52.9 | – | – | – | |||
| N171K | 91.2 | – | + | ||||
| NA | K220N | 96.6 | – | + | – | ||
| V303I | 100 | – | + | – | |||
| N329S | 96.6 | – | + | – | |||
| D339N | 100 | – | + | – |
aThree isolates of each group and wild type virus were chosen as representative strains and the mutations in these strains were listed. Mutation existed: +, mutation didn’t exist: –