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. 2018 Oct 23;8:15615. doi: 10.1038/s41598-018-33689-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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c-Fos expression in human sarcoma samples. (A–C) Co-expression studies of FOS with other genes in a cohort with 259 sarcoma samples. (See Dataset 1 in Supplementary Materials and methods). (A,B Pearson correlation study, p < 0.01). (A) Example of positive correlation between FOS and JUNB gene expression. Each dot represents a sarcoma sample. (B) Example of negative correlation between FOS and BRCA1 gene expression. Each dot represents a sarcoma sample. (C) Gene ontology (GO) study of FOS correlated genes (chi-square with continuity correction study, p < 0.01). A list of significant GO terms with the p-values is provided. The number on the right of each GO term represent the number of genes observed for that GO term. (D) Representative images of performed c-Fos IHC in clinical samples of human sarcomas (Chondrosarcoma n = 29, Osteosarcoma n = 67). (E) Table summarizing the presence of c-Fos in clinical samples of human sarcomas (Fisher’s exact test, p < 0.01). (F,G) c-Fos expression at mRNA level in different sarcoma tumors (*p ≤ 0.1). (F) data extracted from dataset 2, a cohort with 21 sarcoma samples, and normalized to c-Fos expression in growth plate (GP) controls included in the same dataset. (G) data from 19 sarcoma samples extracted from dataset 3 and normalized to HSP90 expression in each patient.