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. 2018 Oct 23;8:15661. doi: 10.1038/s41598-018-33994-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cellular composition in zebrafish ventricles changes with age. Representative histological sections (left) and quantification (right) of zebrafish ventricles at different ages. (A) Ventricles exhibit a gradual increase in myocardial density from 2 to 15 months of age as shown with Masson trichome staining (n ≥ 3) but (B) do not show much change in overall cell and apoptotic cell densities (number per percent myocardial area) as shown with DAPI (blue) and TUNEL (green) staining, respectively (n ≥ 4). (C–E) Ventricles show a significant decrease in fraction of endothelial cells (CD31) (n ≥ 5) (C) and myofibroblasts (α-SMA) (n ≥ 5) (D) from 2 to 7.5 months of age, but a gradual increase in the fraction of cardiomyocytes (MHC) (n ≥ 6) (E). (F) Transmission electron microscopy (TEM) of ventricular myocardium reveals sarcomere length was shorter at 7.5 months than at 2 and 10 months of age (n ≥ 16). Significance between different age groups was determined using Tukey’s pairwise test at p < 0.05.