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. 2018 Oct 23;8:15658. doi: 10.1038/s41598-018-33927-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Expression patterns of tumor CD274 (PD-L1) within the tumor microenvironment of colon carcinoma. (A) Negative CD274 immunohistochemical staining within the tumor microenvironment. (B) Weak cytoplasmic CD274 expression. (C) Strong positive cytoplasmic CD274 expression. (D) Weak cytoplasmic and positive membranous CD274 expression in patients with adenocarcinoma. (E) Moderate positive CD274 expression with a membranous pattern. (F) Strong tumor membranous CD274 expression surrounding high CD274-positive inflammatory cells. Scale bar = 50 μm.