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. 2018 Oct 23;8:15658. doi: 10.1038/s41598-018-33927-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The association of CD8+ TILs and tumor CD274 level in disease-free survival (DFS) among stage II-III colon carcinoma. (A) Stage II-III colon carcinoma patients with high tumor CD274 level within the tumor microenvironment had better 5-year DFS (n = 864, p = 0.0006). (B) High tumor CD274 level in stage II-III MMR-proficient colon carcinoma patients within the tumor microenvironment had improved 5-year DFS (n = 794, p = 0.0006). (C) In stage II-III MMR-deficient colon carcinoma patients, patients with high tumor CD274 level have no association with 5-year DFS (n = 68, p = 0.3298). (D) Stage II-III colon carcinoma patients with high density of CD8+ TILs had better 5-year DFS (n = 867, p < 0.0001). (E) High density of CD8+ TILs in stage II-III MMR-proficient colon carcinoma patients within the tumor microenvironment had improved 5-year DFS (n = 795, p < 0.0001). (F) In stage II-III MMR-deficient colon carcinoma patients, patients with high CD8+ TILs have no association with 5-year DFS (n = 68, p = 0.7552).