Table 3.
Correlation between clinicopathologic parameters, 5-year DFS and 5-year OS.
| Parameters | Noa | 5-yr DFS (%) | p value* | 5-yr OS (%) | p value* |
|---|---|---|---|---|---|
| 867 | 64% | 71% | |||
| Sex | 0.52 | 0.39 | |||
| Female | 401 | 65% | 71% | ||
| Male | 466 | 63% | 70% | ||
| pT stage | 0.02 | 0.13 | |||
| pT1–2 | 32 | 83% | 83% | ||
| pT3–4 | 833 | 63% | 70% | ||
| pN stage | <0.0001* | <0.0001* | |||
| Negative | 457 | 71% | 78% | ||
| Positive | 410 | 56% | 63% | ||
| Tumor location | 0.09 | 0.02 | |||
| Distal colon | 442 | 66% | 74% | ||
| Proximal colon | 425 | 61% | 67% | ||
| Tumor differentiation | 0.01 | 0.02 | |||
| Well to moderate | 734 | 65% | 72% | ||
| Poor | 121 | 54% | 62% | ||
| CD8+ TILs | <0.0001* | <0.0001* | |||
| High | 283 | 78% | 82% | ||
| Low | 584 | 57% | 65% | ||
| Tumor CD274/PD-L1 | 0.0006* | 0.0002* | |||
| High | 384 | 70% | 78% | ||
| Low | 480 | 58% | 65% | ||
| CD8+ TILs/Tumor CD274(PD-L1) | <0.0001* | <0.0001* | |||
| High/High | 160 | 80% | 84% | ||
| High/Low | 123 | 75% | 79% | ||
| Low/High | 224 | 63% | 73% | ||
| Low/Low | 357 | 53% | 60% | ||
| CD8+ TILs and tumor CD274 (PD-L1) | <0.0001* | <0.0001* | |||
| High or high | 507 | 71% | 78% | ||
| Low/Low | 357 | 53% | 60% |
aNumber of cases may differ due to missing data. *p < 0.005 is significant and 0.005 < p < 0.05 is suggestive evidence.