Table 5.
Multivariate analysis of DFS and known prognostic factors in stage II-III colon carcinoma patients.
| Parameters | No. at riska | Events | HR | 95% CI | p value | HR | 95% CI | p value |
|---|---|---|---|---|---|---|---|---|
| Sex | 0.24 | 0.26 | ||||||
| Female | 401 | 133 | 1.00 | 1.00 | ||||
| Male | 466 | 166 | 1.15 | 0.91–1.45 | 1.14 | 0.91–1.44 | ||
| Age | <0.0001* | <0.0001* | ||||||
| <65 | 387 | 103 | 1.00 | 1.00 | ||||
| ≥65 | 480 | 195 | 1.64 | 1.29–2.08 | 1.68 | 1.32–2.13 | ||
| pT stage | 0.009 | 0.007 | ||||||
| T1-2 | 32 | 5 | 1.00 | 1.00 | ||||
| T3-4 | 833 | 227 | 3.26 | 1.34–7.94 | 3.39 | 1.39–8.26 | ||
| pN stage | <0.0001* | <0.0001* | ||||||
| Negative | 457 | 125 | 1.00 | 1.00 | ||||
| Positive | 410 | 173 | 1.83 | 1.45–2.31 | 1.90 | 1.50–2.40 | ||
| Tumor location | 0.04 | 0.06 | ||||||
| Proximal colon | 425 | 157 | 1.00 | 1.00 | ||||
| Distal colon | 442 | 141 | 0.78 | 0.62–0.98 | 0.81 | 0.64–1.01 | ||
| CD8+ TILs | <0.0001 | |||||||
| High | 283 | 60 | 1.00 | |||||
| Low | 584 | 238 | 1.86 | 1.40–2.49 | — | — | ||
| Tumor CD274(PD-L1) | 0.009 | |||||||
| High | 384 | 108 | 1.00 | |||||
| Low | 480 | 190 | 1.37 | 1.08–1.74 | — | — | ||
| CD8+ TILs and tumor CD274(PD-L1) | <0.0001 | |||||||
| High or high | 507 | 137 | 1.00 | |||||
| Low/Low | 360 | 161 | — | — | 1.77 | 1.41–2.22 |
aNumber of cases may differ due to missing data. *p < 0.005 is significant and 0.005 < p < 0.05 is suggestive evidence.