Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Oct 23;9:4408. doi: 10.1038/s41467-018-06557-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — Differential RBP enrichment with eRIC. a Unsupervised clustering and GO analysis of proteins whose enrichments in irradiated (+UV) over non-irradiated (−UV) samples differ significantly between eRIC and RIC (FDR < 0.05 (moderated t test) and FC > 2, 144 proteins). Three main clusters are observed that comprise RBPs preferentially recovered by RIC (top) or eRIC (middle and bottom). Note that proteins in the middle and bottom clusters markedly differ in their enrichment over background in RIC samples. Biological process GO terms enriched for each cluster are shown. Upper: “ribosome biogenesis” (−log10 (p value) = 39.95; enrichment = 40.6), middle: “mRNA processing” (18.36; 14.85), bottom: “mRNA splicing via spliceosome” (33.48; 52.4), “mRNA transport” (8.52; 30.85) and “regulation of mRNA stability” (4.04; 17.08) (Fisher’s Exact with FDR multiple test correction). b Fold change in irradiated over non-irradiated samples of representative example RBPs captured by eRIC and RIC. Data correspond to two biologically independent experiments (a, b); in b, data are shown as mean