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. 2018 Oct 17;9:2334. doi: 10.3389/fimmu.2018.02334

Figure 1.

Figure 1

ATG5 in canonical and non-canonical autophagy. ATG5 is involved in both canonical and non-canonical autophagy processes. The left side of the figure shows how ATG5 is implicated in the process of macroautophagy. Upon binding with ATG12 and ATG16, ATG5 forms a complex to conjugate PE with LC3, which is deposited on the membrane of the autophagosome. ATG5 is also expressed on the autophagosomal membrane that binds with TECRP, and therefore promotes the fusion of autophagosomes and the lysosomes. The right side of the figure presents ATG5 involved in the process of LAP. Similarly, ATG5 helps the conjugation of LC3 and PE by forming a complex of ATG5-ATG12-ATG16, and thus accomplishes the deposition of LC3-PE on the phagosome.