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. 2018 Oct 17;9:2334. doi: 10.3389/fimmu.2018.02334

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Copyright © 2018 Ye, Zhou and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ATG5 in the development of lymphocytes. ATG5 regulates the proliferation and differentiation of lymphocytes in each stage (1). Autophagy regulates the status of hematopoietic stem cell (HSC) through modulating the level of reactive oxygen species (ROS). Deletion of ATG5 in HSC inhibits autophagy and results in loss of self-renewability (2). ATG5 regulates lymphocyte maturation via autophagy in both bone marrow and thymus. Loss of ATG5 in this stage results in maturation failure and autoimmunity (3). ATG5 is responsible for the homeostasis of peripheral lymphocytes. Deletion of ATG5 in peripheral lymphocytes exhibit cell potency like autoimmunity.