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ATG5 in apoptosis. ATG5 is able to bind with Fas associated protein with death domain (FADD) to block the binding of death-induced signaling complex (DISC) and FADD, and thus inhibits extrinsic apoptosis. ATG5 can also be cleaved by Calpains. The cleaved products then are translocated to the mitochondria to bind with Bcl-xL, and promote the secretion of cytochrome c, which activates intrinsic apoptosis.
