Figure 1.

Gap19 decreased infarct volume and prevented the deterioration neurological deficit after ischemia/reperfusion (I/R) injury. Mice were administered Gap26 or Gap19 1 h after middle cerebral artery occlusion (MCAO). 2,3,5-triphenyltetrazolium chloride chloride (TTC) staining and neurological scores were examined at 24 h after reperfusion. (A) Representative TTC-stained slices of different treatment groups after MCAO. The infarct tissue area was not stained (white), and normal tissue was stained (red). (B,C) Statistical analyses of infarct volume of different treatment groups were shown. (C) Neurological scores were assessed with a 5-point scale system. Gap19 treatment observably decreased neurological deficits. Data represent mean ± SEM of five brains. *P < 0.05 vs. I/R group, ^#,&P < 0.05.